Endocrine Abstracts

Isolated growth hormone deficiency (IGHD) type 1a is caused by defects of the GH-I gene resulting in severe short stature. Treatment with growth hormone may become ineffective due to significant production of growth hormone antibodies. However, this has only been reported in patients treated with pituitary derived growth hormone. We present five cases with IGHD type 1a successfully treated with recombinant human growth hormone (rhGH).Five patients from f...

Background: Obesity is a rising problem in developed and developing countries. Currently little is known about prevalence and prognosis of type 2 diabetes and the metabolic syndrome in obese children and adolescents in Europe.Patients and methods: About 491 obese children (mean-age 11.2 years; mean-BMI 30.3 kg/m2) were examined (lipid-profile; blood pressure, insulin-resistance1) and in 102 of them with risk factors for type 2 diabe...

Objective: MODY5 is caused by abnormalities in the TCF2 gene encoding the transcription factor HNF1β. We investigated cases of MODY5 for the underlying type of TCF2 anomaly.Case presentations: From 623 children and adolescents with diabetes mellitus followed at our diabetes clinic in 2006, 64 were negative for islet cell autoantibodies (GAD, IA-2, ICA) within the first year of diagnosis and out of these, four patients presented clinica...